102 CXCL9 drives morphea pathogenesis in mice

Chemokine Cxcl9 attenuates liver fibrosis-associated angiogenesis in mice.

UNLABELLED Recent data suggest that the chemokine receptor CXCR3 is functionally involved in fibroproliferative disorders, including liver fibrosis. Neoangiogenesis is an important pathophysiological feature of liver scarring, but a functional role of angiostatic CXCR3 chemokines in this process is unclear. We therefore investigated neoangiogenesis in carbon tetrachloride (CCl(4))-induced liver...

Redox State Drives the Pathogenesis of Hypertension

17 Obstructive sleep apnea (OSA) is one of the most common causes of hypertension 18 in western societies. OSA causes chronic intermittent hypoxia (CIH) in specialized O 2-19 sensing glomus cells of the carotid body. CIH generates increased reactive oxygen 20 species (ROS) that trigger a feed-forward mechanism in which increased intracellular 21 calcium levels ([Ca 2+ ] i) trigger increased HIF...

Circadian pharmacology of L-alanosine (SDX-102) in mice.

L-alanosine (SDX-102) exerts its cytotoxicity through inhibition of de novo purine biosynthesis, an effect potentiated by methylthioadenosine phosphorylase (MTAP) deficiency. The relevance of circadian dosing time was investigated for chronotherapeutic optimization of SDX-102. Toxicity was assessed in healthy mice following single (1,150, 1,650, or 1,850 mg/kg/d) or multiple doses (250 or 270 m...

The role of dendritic cells and regulatory T cells in the pathogenesis of morphea

Morphea is one of diseases characterised by fibrosis of the skin and subcutaneous tissue. It is a chronic disease that does not shorten the life of the patient, yet significantly affects its quality. The group of factors responsible for its pathogenesis is thought to include disturbed functioning of endothelial cells as well as immune disturbances leading to chronic inflammatory conditions, acc...

Inflammasome-Dependent IFN-g Drives Pathogenesis in Streptococcus pneumoniae Meningitis